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Herpes  Herpes is a sexually transmitted disease (STD) caused by the Herpes Simplex Virus (HSV). HSV-type 1 commonly causes fever blisters on the mouth or face (oral herpes), while HSV-type 2 typically affects the genital area (genital herpes). However, both viral types can cause either genital or oral infections. Most of the time, HSV-1 and HSV-2 are inactive or "silent," and cause no symptoms. However, some infected people have outbreaks of blisters and ulcers. Once infected with HSV, people remain infected for life. Oral herpesOral herpes is an infection caused by the herpes simplex virus that causes painful sores on your lips, gums, tongue, roof of your mouth, and inside your cheeks. It also can cause symptoms such as fever and muscle aches. The herpes simplex virus affects only humans. Mouth sores most commonly occur in children aged 1-2 years, but they can affect people at any age and any time of the year. People contract herpes by touching infected saliva, mucous membranes, or skin. Because the virus is highly contagious, most people have been infected by at least 1 herpes subtype before adulthood.The stages of oral herpesAfter the herpes virus infects you, it has a rather unique ability to proceed to 3 stages.
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Herpes Medical Studies Herpes (HSV-1, HSV-2)Antiviral activity of Melissa officinalis and other plant extracts against Herpes simplex virus type-2.Allahverdiyev A, Duran N, Ozguven M, Koltas S.Tropical Diseases Center, Faculty of Medicine, Cukurova University, Adana, Turkey. Melissa officinalis L. (Lamiaceae)and other plant extracts have been used in a variety of practical applications in medical science. Our objective in the current study was to determine the effects of the volatile oil components of M. officinalis on Herpes simplex virus type 2 (HSV-2) replication in HEp-2 cells. Four different concentrations (25, 50, 100, 150 and 200 microg/ml) of volatile oils were examined. Experiments were carried out using HEp-2 cells. M. officinalis volatile oil was found to be non-toxic to HEp-2 cells up to a concentration of 100 micro/ml. It was, however, found to be slightly toxic at a concentration over of 100 microg/ml. The antiviral activity of non-toxic concentrations against HSV-2 was tested. The replication of HSV-1, and HSV-2 was inhibited, indicating that the M. officinalis and other plant extracts contain anti-HSV-2 substances. PMID: 15636181 [PubMed - indexed for MEDLINE] Antiviral activity of Australian Melaleuca alternifolia and eucalyptol plant extracts against herpes simplex virus in cell culture.Schnitzler P, Schon K, Reichling J.Department of Virology, Hygiene Institute, University of Heidelberg, Germany. The antiviral effect of Melaleuca alterfernolia (TTO) and eucalyptol (EUO) and other plant extracts against herpes simplex virus was examined. Cytotoxicity of TTO and EUO was evaluated in a standard neutral red dye uptake assay. Toxicity of TTO and EUO was moderate for RC-37 cells and approached 50% (TC50) at concentrations of 0.006% and 0.03%, respectively. Antiviral activity of TTO and EUO against herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) was tested in vitro on RC-37 cells using a plaque reduction assay. The 50% inhibitory concentration (IC50) of TTO for herpes simplex virus plaque formation was 0.0009% and 0.0008% and the IC50 of EUO was determined at 0.009% and 0.008% for HSV-1 and HSV-2, respectively. Australian tea tree oil exhibited high levels of virucidal activity against HSV-1 and HSV-2 in viral suspension tests. At noncytotoxic concentrations of TTO plaque formation was reduced by 98.2% and 93.0% for HSV-1 and HSV-2, respectively. Noncytotoxic concentrations of EUO reduced virus titers by 57.9% for HSV-1 and 75.4% for HSV-2. Virus titers were reduced significantly with TTO, whereas EUO exhibited distinct but less antiviral activity. In order to determine the mode of antiviral action of both essential oils, either cells were pretreated before viral infection or viruses were incubated with TTO or EUO before infection, during adsorption or after penetration into the host cells. Plaque formation was clearly reduced, when herpes simplex virus was pretreated with the essential oils prior to adsorption. These results indicate that TTO and EUO affect the virus before or during adsorption, but not after penetration into the host cell. Thus TTO and EUO are capable to exert a direct antiviral effect on HSV. Although the active antiherpes components of Australian tea tree and eucalyptus oil are not yet known, their possible application as antiviral agents in recurrent herpes infection is promising. PMID: 11338678 [PubMed - indexed for MEDLINE] PMID: 6423612 [PubMed - indexed for MEDLINE] Herpes Labialis (Cold Sores) & Extract (Lo-701) for topical treatment of recurring herpes labialis.Koytchev R, Alken RG, Dundarov S.Cooperative Clinical Drug Research and Development GmbH, Berlin, Germany. ccdrd@drug-news.com A double-blind, placebo-controlled, randomized trial was carried out with the aim of proving efficacy of standardized balm mint cream [active ingredient: 1% Lo-701--extract from Melissa officinalis (70:1)] for the therapy of herpes simplex labialis. Sixty six patients with a history of recurrent herpes labialis (at least four episodes per year) in one center were treated topically; 34 of them with verum and 32 with placebo. The cream had to be smeared on the affected area four times daily over five days. A combined symptom score of the values for complaints, size of affected area and blisters at day 2 of therapy was formed as the primary target parameter. There was a significant difference in the values of the primary target parameter between both treatment groups: verum 4.03 +/- 0.33 (3.0); placebo 4.94 +/- 0.40 (5.0); values given are mean +/- SEM (median) of the symptoms score on day 2 of therapy. The tested formulation is effective for the treatment of herpes simplex labialis. The significant difference in the combined symptom score on the second day of treatment is of particular importance having in mind that the complaints in patients suffering from herpes labialis are usually most intensive at that time. In addition to the shortening of the healing period, the prevention of a spreading of the infection and the rapid effect on typical symptoms of herpes like itching, tingling, burning, stabbing, swelling, tautness and erythema, the balm mint cream has a further advantage. The different mechanism of action of the extract rules out the development of resistance of the herpes virus. Some indication exists that the intervals between the periods with herpes might be prolonged with melissa. Publication Types: Clinical Trial Randomized Controlled Trial PMID: 10589440 [PubMed - indexed for MEDLINE] »view more medical studies
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